Transactions on Mass-Data Analysis of Images and Signals (ISSN:1868-6451)

Volume 7 - Number 1 - September 2017 - Page 31-40

Ultrasound-assisted Supercritical Carbon Dioxide Extraction of Ursolic Acid from Rabdosia rubescens

Yu-Chiao Yang1, Pei-Hui Lin2, Jin-Ming Chen3, Yu-Tuan Chou 3, and Ming-Chi Wei3*

1 Department and Graduate Institute of Pharmacology, Kaohsiung Medical University, Taiwan 2 Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA 3 Department of Applied Geoinformatics, Chia Nan University of Pharmacy and Science, Taiwan


Ursolic acid (UA) exhibits an antineoplastic activity on several kinds of cancer. In this study, the temperature of 32–64 °C and pressure of 11.0–32.0 MPa were used to extract UA from Rabdosia rubescens using ultrasound-assisted supercritical carbon dioxide (USC–CO2) with ethanol solution as a cosolvent. The optimized condition for maximal extraction yield of UA using USC–CO2 process was at a pressure of 28.5 MPa and temperature of 55 °C with 11.6% of ethanol (80%, v/v) as cosolvent, leading to the extraction yield of 2.386 mg/g dry plant weight. Comparing with other conventional methods, USC–CO2 extraction revealed superior extraction yield and efficiency. In conclusion, USC–CO2 procedure can be considered as a promising green alternative to extract UA from R. rubescens for food, cosmetic and pharmaceutical industries with benefits of no chemical waste, rich in active compounds and short extraction time.

Keywords: Rabdosia rubescens, ursolic acid, ultrasound-assisted supercritical CO2 extraction, cosolvent

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